Testing for Hardy-Weinberg Equilibrium in Samples With Related Individuals
نویسندگان
چکیده
منابع مشابه
Testing for Hardy-Weinberg equilibrium in samples with related individuals.
When the classical chi(2) goodness-of-fit test for Hardy-Weinberg (HW) equilibrium is used on samples with related individuals, the type I error can be greatly inflated. In particular the test is inappropriate in population isolates where the individuals are related through multiple lines of descent. In this article, we propose a new test for HW (the QL-HW test) suitable for any sample with rel...
متن کاملTesting for Hardy-Weinberg Equilibium in Samples with Related Individuals
3 SUMMARY When the classical χ 2 goodness-of-fit test for Hardy-Weinberg (HW) equilibrium is used on samples with related individuals, the type I error can be greatly inflated. In particular the test is inappropriate in population isolates where the individuals are related through multiple lines of descent. In this paper, we propose a new test for HW (the QL-HW test) suitable for any sample wit...
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Hardy-Weinberg equilibrium (HWE) holds when, in a closed population with random mating and without mutation and natural selection, genotype frequencies at any locus is a simple function of allele frequencies. Testing for HWE is now a common practice in population genetics and genetic association studies of non-communicable diseases; however, it is less-regarded, or sometimes miss-interpreted, i...
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Hardy-Weinberg Equilibrium should be checked in every genetic association study, to guard against genotyping errors and population stratification. When the sample contains related individuals, the usual likelihood ratio test becomes difficult to implement and typically the test is applied to one individual selected at random from each family. This results in a loss of power, particularly where ...
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We analyze the general (multiallelic) Hardy-Weinberg equilibrium problem from an objective Bayesian testing standpoint. We argue that for small or moderate sample sizes the answer is rather sensitive to the prior chosen, and this suggests to carry out a sensitivity analysis with respect to the prior. This goal is achieved through the identification of a class of priors specifically designed for...
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ژورنال
عنوان ژورنال: Genetics
سال: 2004
ISSN: 1943-2631
DOI: 10.1534/genetics.104.031617